M.C.A.S Mast Cell Activation Syndrome (MCAS) Advanced Test


Out of stock

Email when stock available



Mast Cell Activation Syndrome (MCAS) is a condition where a patient may have a normal level of mast cells present, but these cells may be over-responsive or overreact to the body.  Symptoms are usually related to the excess and episodic release of inflammatory mediators from mast cells. A common presentation is recurrent anaphylaxis where no trigger or cause can be identified. It is often a challenging condition to detect because the inflammatory mediators may only be released during an episode, then return to normal levels. For example, if the patient is amidst a flare-up they may or may not have an elevated serum tryptase level.

Common Conditions

  •  Itching (pruritus)
  •  Hives
  •  Swelling
  •  Skin Flushing ie. skin turning red
  •  Wheezing
  •  Shortness of breath
  •  Heart symptoms (low blood pressure, rapid heart rate)

The MCAS Profile Advanced assesses all analytes in 3409 and 3410 as well as Diamone Oxidase and Total IgE. Diamine Oxidase is the enzyme responsible for clearing histamine in the body and excess histamine may be related to dysfunctional diamine oxidase. Total IgE test measures the amount of IgE antibody in the blood. Allergies are a common condition that affects the body’s immune system. When the body has an allergic reaction, a normally harmless trigger substance such as dust, pollen or specific foods, initiates an immune response via production of an antibody called immunoglobulin IgE. A high detection of Total IgE in a blood sample may mean there are one or more allergies. This test measures the total number of IgE antibodies in the blood, which differs from the specific IgE test that measures IgE responses to various allergens. Total IgE may be elevated in MCAS patients.

Testing for:

  • Tryptase
  • Chromogranin A
  • WB Histamine
  • Prostaglandin D2
  • Leukotriene E4
  • 2,3-Dinor-11b-Prostaglandin F2a
  • N-methyl-Histamine
  • DAO
  • Total IgE

Have any questions about this test?  Ask one of our qualified health practitioners here.

You may also like…