M.C.A.S Mast Cell Activation Syndrome (MCAS) Extensive test


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Mast Cell Activation Syndrome (MCAS) is a condition where a patient may have a normal level of mast cells present, but these cells may be over-responsive or overreact to the body.  Symptoms are usually related to the excess and episodic release of inflammatory mediators from mast cells. A common presentation is recurrent anaphylaxis where no trigger or cause can be identified. It is often a challenging condition to detect because the inflammatory mediators may only be released during an episode, then return to normal levels. For example, if the patient is amidst a flare-up they may or may not have an elevated serum tryptase level.

Common Conditions

  •  Itching (pruritus)
  •  Hives
  •  Swelling
  •  Skin Flushing ie. skin turning red
  •  Wheezing
  •  Shortness of breath
  •  Heart symptoms (low blood pressure, rapid heart rate)

The MCAS Profile- Extensive assesses in a urine sample Prostaglandin D2, Leukotriene E4, and 2,3 Dinor-11b-Prostaglandin F2a. Prostaglandin D2 is a major inflammatory mediator produced by Mast Cells. Leukotriene E4 is also one of the inflammatory molecules that could be released by mast cells during an attack or flare-up. 2,3 dinner-11beta-prostaglandin F2-alpha is a marker used in the screening of Mast cell activation disorders. N-methyl-histamine is a major histamine metabolite that is produced in the mast cells. Excess levels are seen in Mast Cell Activation Syndrome.

Testing for:

  • Prostaglandin D2
  • Leukotriene E4
  • 2,3-Dinor-11b-Prostaglandin F2a
  • N-methyl-Histamine

Have any questions about this test?  Ask one of our qualified health practitioners here.

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