M.C.A.S Mast Cell Activation Syndrome (MCAS) Test Basic

Mast Cell Activation Syndrome (MCAS) is a condition where a patient may have a normal level of mast cells present, but these cells may be over-responsive or overreact to the body.  Symptoms are usually related to the excess and episodic release of inflammatory mediators from mast cells. A common presentation is recurrent anaphylaxis where no trigger or cause can be identified. It is often a challenging condition to detect because the inflammatory mediators may only be released during an episode, then return to normal levels. For example, if the patient is amidst a flare-up they may or may not have an elevated serum tryptase level.

The MCAS Profile – 3409 basic profile includes some of the basic inflammatory mediators that may be released in Mast Cell Activation syndrome. For example, these include Tryptase, Chromogranin A, Whole Blood Histamine. Tryptase is a serine protease that is released during mast cell degranulation. Chromogranin A is another inflammatory mediator used to identify MCAS.

Common Conditions

•  Itching (pruritus)
•  Hives
•  Swelling
•  Skin Flushing ie. skin turning red
•  Wheezing
•  Shortness of breath
•  Heart symptoms (low blood pressure, rapid heart rate)

Testing for:

• Tryptase
• Chromogranin A
• WB Histamine