Estrogen Metabolites Spot Urine Test




The estrogen metabolite tests detect the urinary products of estrogen metabolism. The metabolites have their own specific biological actions; some have the stimulatory properties of estradiol, whilst others are weak and protective estrogen molecules. An imbalance in estrogen metabolism has been associated with osteoporosis, high blood pressure, lupus, and cancer (breast, endometrial, prostate, thyroid, head, and neck). As estrogen metabolites are modifiable by lifestyle and nutritional changes, this test is useful for not only establishing risk but monitoring therapies that can reduce the probability of these disorders.

Estrogen has positive effects on the cardiovascular system, bones, brain, skin as well as reproductive organs. The issues experienced at menopause such as memory loss, osteoporosis, and vaginal dryness validates the importance of maintaining optimal estrogen levels. However, if you have too much estrogen in the body, it may increase the risk of hormone-related cancers such as endometrial, prostate, and breast cancer.

The view that all estrogens are ‘bad’ and cause cancer is a simplistic one. Estradiol (E2) and estrone (E1) are metabolized into at least 14 different species. These breakdown products have their own specific biological actions; some have the stimulatory properties of estradiol whilst others are weak and antagonistic to other estrogen molecules. An imbalance of the stimulatory versus weak estrogen metabolites has been observed to be associated with many different health disorders. Whilst high levels of the 16α-hydroxyestrone stimulatory estrogen raise cancer risk, lower levels are associated with osteoporosis. In contrast, if the weak estrogens are high they protect against cancer but inhibit bone growth. Therefore the estrogen metabolites are not inactive excretion products but powerful molecules in their own right and should be monitored.

Common Conditions:

  • Fatigue
  • Depression
  • Poor libido
  • Poor memory
  • Hot flushes
  • Cancer
  • Hormonal imbalances
  • Menopausal symptoms
  • Andropausal symptoms

The Estrogen Test

The estrogen test is a simple urine test that can be done right from your home or office.  The test evaluates the levels of 4 important estrogen markers such as:

Estrone (E1)
Estrone (E2)
Estrone (E3)
2-Hydroxy Estradiol (2OHE2)
2-Hydroxy Estrone (2OHE1)
4-Hydroxy Estradiol (4OHE2)
4-Hydroxy Estrone (4OHE1)
16α-Hydroxy Estrone (16aOHE1)
2-Methoxy Estradiol 2(MeOE2)
2-Methoxy Estrone 2(MeOE1)
4-Methoxy Estradiol 4(MeOE2)
4-Methoxy Estrone 4(MeOE1)

The test includes:

  • The test kit
  • The test kit full instructions
  • Express post overnight return delivery to the laboratory
  • Test results are sent to one of our professional health practitioners within 10-12 business days for evaluation.  Our practitioners contact you with the results and recommendations on any findings via email, mail or phone so you’ll know exactly what you need to do if the results come back positive.

Turnaround time 12-15 Business days