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Gut Immunity Test Secretory IgA (sIgA)




Does your gut have good immunity?

Secretory IgA (sIgA) is found in high concentrations in the secretions of the gastrointestinal, genitourinary and respiratory mucosal linings. The most recognised function of sIgA includes its role in ‘immune exclusion’ in which it prevents viruses, bacteria and other antigens adhering to and penetrating epithelial mucosa. SIgA may also inhibit inflammatory processes that damage the mucosa and preliminary evidence suggests that it may play a role in inducing an antigen specific immune response by a non-inflammatory mechanism. A sIgA deficiency may lower resistance to infection.

The gastrointestinal, genitourinary and respiratory mucosal linings represent extensive surfaces for potential assault by microbes. Secretory IgA (sIgA) is found in high concentrations in the secretions that bathe these mucosal cells where it acts as the chief antibody in the first line of immune defence. It is a very stable molecule which is resistant to degradation and therefore functions well in the harsh environment of the gastrointestinal tract. SIgA is thought of predominantly as a first line of defence as part of the innate immune response, whereas serum IgA is part of the adaptive immune response. In comparison to serum IgA, the functions of sIgA (secretory IgA) are not dependent on the specificity of the IgA molecule.

SIgA can prevent antigens, including viruses, bacteria and bacterial toxins and enzymes, adhering to and penetrating the luminal epithelial mucosa. SIgA complexes with the antigens which facilitates their elimination by peristalsis or mucociliary movements.

Common Conditions:

  • Autoimmune disorders
  • Asthma
  • Food sensitivities
  • Recurrent infections
  • Viral infections
  • Coeliac disease
  • Gut dysbiosis
  • IBS (irritable bowel syndrome)

About the Secretory IgA (sIgA) Test

The Secretory IgA (sIgA) test is a simple home test kit that enables you to take stool samples using the kit and instructions are provided, the kit includes everything you need to take the test at home and includes express postage to send your test samples back to the laboratory.
Test results are sent to one of our professional health practitioners within 5 business days for evaluation.  Our practitioners contact you with the results and recommendations on any findings via email, mail or phone.