Estrogen Metabolites Level 3-24 Hour Urine Test


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The estrogen metabolite assessment detects the urinary products of estrogen metabolism. The metabolites have their own specific biological actions; some have the stimulatory properties of estradiol, whilst others are weak and protective estrogen molecules. An imbalance in estrogen metabolism has been associated with osteoporosis, high blood pressure, lupus, and cancer (breast, endometrial, prostate, thyroid, head, and neck). As the estrogen metabolites are modifiable by lifestyle and nutritional changes, this test is useful for not only establishing risk but monitoring therapies that can reduce the probability of these disorders.

Estrogen has positive effects on the cardiovascular system, bones, brain, skin as well as reproductive organs. The issues experienced at menopause such as memory loss, osteoporosis, and vaginal dryness validate the importance of maintaining optimal estrogen levels. However, if you have too much estrogen in the body, it may increase the risk of hormone-related cancers such as endometrial, prostate, and breast cancer.

The view that all estrogens are ‘bad’ and cause cancer is a simplistic one. However, Estradiol (E2) and Estrone (E1) are metabolized into at least 14 different species. These breakdown products have their own specific biological actions; some have the stimulatory properties of estradiol whilst others are weak and antagonistic to other estrogen molecules. An imbalance of the stimulatory versus weak estrogen metabolites has been observed to be associated with many different health disorders. Whilst high levels of the 16α-hydroxyestrone stimulatory estrogen raise cancer risk, lower levels are associated with osteoporosis. In contrast, if the weak estrogens are high they protect against cancer but inhibit bone growth. Therefore the estrogen metabolites are not inactive excretion products but powerful molecules in their own right and should be monitored.

The estrogen metabolites profile level 3 is the most comprehensive assessment as it looks at a comprehensive scope of estrogen metabolites for the prevention and treatment of estrogen-related symptoms and conditions. This robust urine analysis is ideal for monitoring and assessing the risk of estrogen-related diseases.

Common Conditions:

  • Anxiety
  • Osteoporosis
  • Depression
  • Uterine Fibroids
  • Fatigue
  • Insomnia
  • Poor Memory
  • Headaches/Migraines
  • Loss of libido
  • Immune dysregulation
  • Cancer
  • Mood Disorders
  • Fatigue
  • Cardiovascular disease
  • Menopausal symptoms
  • Joint pain
  • Premenstrual syndrome
  • Muscle pain

This test is a 24 hour urine test kit. A test kit will be posted to you with full instructions including prepaid return postage to the laboratory.  The following markers will be tested:

Estrone (E1)
Estrone (E2)
Estrone (E3)
2-Hydroxy Estradiol (2OHE2)
2-Hydroxy Estrone (2OHE1)
4-Hydroxy Estradiol (4OHE2)
4-Hydroxy Estrone (4OHE1)
16α-Hydroxy Estrone (16aOHE1)
2-Methoxy Estradiol 2(MeOE2)
2-Methoxy Estrone 2(MeOE1)
4-Methoxy Estradiol 4(MeOE2)
4-Methoxy Estrone 4(MeOE1)

Turn around time

10-12 Business days